What are the nouns NAD+/ Coenzyme /NMN?

Relationship between NAD+ and NMN

NAD+ (Coenzyme I, full name nicotinamide adenine dinucleotide) is a key coenzyme in the tricarboxylic acid cycle, widely involved in the metabolism of sugars, fats and amino acids, and plays an important role in energy synthesis.

It exists in every cell and is involved in thousands of biochemical reactions.

NMN

A large number of experimental studies have shown that NAD+ is widely involved in many basic physiological activities in the human body, regulating key cellular functions such as energy metabolism, DNA repair, gene expression, inflammatory response, biological rhythm, and stress resistance.

Studies have shown that with the increase of age, the concentration of NAD+ in the human body will gradually decline, and the decline of NAD+ level is closely related to aging phenomena such as neurodegenerative diseases, visual loss, obesity, and decreased heart function.

How to improve the level of NAD+ in vivo has become an important research direction in the field of biomedicine.

Whta is NMN?

NMN (nicotinamide mononucleotide) is a direct precursor of NAD+, a substance that occurs naturally in the human body and is widely present in some foods.

The NMN molecule can easily cross the cell membrane, and once inside the cell, the two NMN molecules will combine to form NAD+.

Because NMN is quickly absorbed by the body, it is considered an effective way to increase NAD+ levels.

Which foods contain NMN?

NMN (niacinamide mononucleotide) occurs naturally in a variety of plant and animal foods, and the NMN required by the human body can be ingest through the daily diet.

Because the NMN content in food is usually low, it is often not enough to meet the entire needs of the human body, generally no more than 2 mg per 100 grams of food.

Edamame: 0.47-1.88mg /100g
Broccoli: 0.25-1.12mg /100g
Cucumber seeds :0.56 mg /100g
Cucumber peel :0.65 mg /100g
Cabbage :0-0.9 mg /100g
Avocados :0.36-1.6 mg /100g
Tomatoes :0.26-0.3 mg /100g
Mushrooms :0-1.01 mg /100g
Beef :0.06-0.42 mg /100g
Shrimp: 0.22 mg /100g

discovery and industrialization of NMN activity

In 2005, Professor Shinjiro Imai of Washington University in St. Louis initiated ongoing research on NMN.
In 2009, Miao Chaoyu, a professor at the Second Military Medical University in Shanghai, received a patent for the treatment of stroke with NMN.
In 2011, Professor Shinjiro Imai cooperated with OYC Company in Japan to develop NMN and successfully produced a small sample.
In 2013, Harvard University professor David Sinclair published a paper in the global authoritative journal "Cell", saying that by using NMN to increase the level of NAD+, the life span of laboratory mice was extended by 30% after a week.
In 2016, the University of Washington conducted a human clinical trial of NMN in collaboration with Keio University in Japan to evaluate metabolically relevant parameters and explore the potential of NMN as a functional food.
In 2016, NMN was first productized by Shinkowa, a Japanese company, but the cost of taking NMN was as high as 20,000 yuan per month.
In 2019, Japan's Ministry of Health, Labor and Welfare included NMN on its "non-medical list," allowing its use in food production.
In 2020, GSHWORLD, as a leading company in the industry, will play an important role in driving the adoption of NMN. GSHWORLD uses advanced biological enzyme method to produce NMN, which not only improves the purity of the product, but also effectively controls the production cost, making NMN move from the high-end market to the mass consumption level.
In 2021, researchers at the University of Washington School of Medicine in the United States published research results in the journal Science, finding that NMN can improve skeletal muscle insulin sensitivity in postmenopausal pre-diabetic women, and help improve gene expression related to muscle structure and remodeling.

In SUMMARY:

The research and commercialization process of NMN has not only brought new breakthroughs in the field of anti-aging, but also provided more accessible healthy choices for consumers around the world.

GSHWORLD, with its innovative production process and high-quality products, has taken a leading position in this field and promoted the popularization and market development of NMN.