Water soluble coenzyme Q10 and fat soluble coenzyme Q10

Heart protectant Coenzyme Q10

Water-soluble Coenzyme Q10 and fat-soluble Coenzyme Q10 are two different forms of Coenzyme Q10, which have some differences in absorption rate, application and preparation.

01 Definitions and properties

Fat-soluble coenzyme Q10

Coenzyme Q10 itself is a fat-soluble compound, soluble in organic solvents (such as chloroform, benzene, carbon tetrachloride, etc.), insoluble in water.

Fat-soluble coenzyme Q10 is absorbed by the body through active transport, and the absorption rate is relatively fast.

Water soluble coenzyme Q10

Strictly speaking, coenzyme Q10 itself is not soluble in water, and the so-called water-soluble coenzyme Q10 is achieved by means of preparation.

Water-soluble Coenzyme Q10 is usually prepared by containing coenzyme Q10 solids in microcrystalline fiber substances such as water-soluble starch or gamma-cyclodextrin, and adding antioxidants (such as vitamin E) and stabilizers (such as glycerin).

This form allows coQ10 to form a uniform solution in water, thereby increasing its bioavailability.

02 Absorption rate and application

Absorption rate

Fat-soluble coenzyme Q10 is easier to be absorbed by the body because of its own fat-soluble properties, and the absorption rate is relatively fast.

Although water-soluble coenzyme Q10 has improved its solubility in water by means of preparation, the absorption rate may be relatively slow.

Due to its longer residence time in the body, the drug absorption time is correspondingly extended.

Apply

Fat-soluble coQ10 is widely used in medicines and cosmetics because it is easily absorbed by the skin and exerts antioxidant effects.

Water-soluble coenzyme Q10 is more suitable for making into drinks, food, tablets and capsules, etc., to facilitate People's Daily supplement.

Due to its good water solubility, it is also more suitable for the preparation of oral liquid preparations.

03 Preparation and stability

preparation

The preparation of fat-soluble coenzyme Q10 is relatively simple because coenzyme Q10 itself is fat-soluble.

The preparation of water-soluble coenzyme Q10 requires specific preparation means, such as using water-soluble excipients to wrap coenzyme Q10 into particles or adding emulsifiers to form oil-in-water particles.

stability

Coenzyme Q10 is easily decomposed under light, so whether it is a fat-soluble or water-soluble form, attention needs to be paid to avoid light during preparation and storage.

Water-soluble Coenzyme Q10 may improve its stability to a certain extent due to the addition of antioxidants and stabilizers.