It not only poses a threat to people health but also causes widespread concern. In recent years, a substance called NMN has attracted much attention and is considered to potentially beneficial to the immune system.
As an acute respiratory infectious disease caused by influenza virus, its typical symptoms include fever, cough, sore throat, nasal congestion, muscle or joint pain, fatigue and headache, etc.
NAD+ declines with age
NMN, as a precursor of vitamin B3, participates in a variety of biological processes. These include energy metabolism, DNA repair, gene expression regulation, etc. As age increases, the NAD+ level in the human body will gradually decrease, which will lead to a decrease in cell function and immunity.
NMN increases NAD levels in the body
The Toyama University research team measured the NAD metabolome in whole blood at 0, 4, 8, 12 and 16 weeks before participants started taking NMN or placebo (4 weeks after completing β-Nicotinamide Mononucleotide or placebo administration).
The results showed that NAD levels increased significantly at 4, 8, and 12 weeks after oral administration of NMN, and returned to the basic level after 16 weeks.
These studies show that supplementing NMN can effectively increase the level of NAD+ in the body, thereby improving cell function and improving immunity, which is of great significance for maintaining physical health and improving physical fitness.
NMN helps body function
To further explore the potential benefits of β-Nicotinamide Mononucleotide, Okumura’s team at the University of Tsukuba in Japan conducted a randomized, double-blind placebo-controlled research experiment. Researchers divided 108 older people into four groups and gave them NMN (250 mg) or a placebo every day for 12 weeks.
And the researchers evaluated the physical function of the older people by using grip strength, 5-sit-to-stand time (5-STS), starting time and 5-meter walking time. The results showed that compared with before administration, the sleepiness of the older people after administration was significantly improved.
Overall, taking NMN in the afternoon can effectively improve lower limb function and reduce sleepiness in the older people. These findings suggest that β-Nicotinamide Mononucleotide has the potential to prevent physical decline and improve fatigue in the older people.
NMN inhibits inflammatory pathways
Further research suggests that NMN may also have a positive impact on the activity of immune cells. Through metabolomic analysis of activated macrophages, the Tsinghua University research team found that supplementing β-Nicotinamide Mononucleotide not only increased NAD levels in activated cells, but also reduced the production of cytokines.
In addition, NMN can also reduce the expression of inflammation-related proteins and inhibit inflammation-related pathways, thereby regulating its immune function. These findings further support the idea that β-Nicotinamide Mononucleotide may enhance the anti-cancer activity of immune cells.
NMN can strengthen the immune system
In addition, an academic paper published by a team from the Chinese Academy of Sciences in Cell Discovery pointed out that supplementing NMN has a similar effect to NAD+ in preventing and treating the new coronavirus. This finding supports the benefits of NMN on the immune system.
Supplementing NMN can not only improve the NAD+ metabolic disorder caused by infection with the new coronavirus, but also improve the imbalance of immune response and cell death-related gene expression, and inhibit the occurrence of cell death.
β-Nicotinamide Mononucleotide can also promote cells to produce antibodies, enhance the effect of immune T cells, and affect the production of immunoglobulins in the body, thus having an important immunoregulatory effect.
In addition to its role in the immune system,
more and more studies have found that NMN also reveals its various biological activities in the fields of delaying aging, improving cognition, protecting vision, preventing cardiovascular and cerebrovascular diseases, and improving sleep.
In general, NMN,
as a substance with multiple biological activities, has shown a positive impact on the immune system in scientific research. By increasing NAD+ levels in the body, NMN helps improve cell function and immunity, supporting good health.
- Song Q, Zhou X, Xu K, Liu S, Zhu X, Yang J. The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update. Adv Nutr. 2023 Aug 22:S2161-8313(23)01359-5.
- Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T. Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022 Feb 11;14(4):755.
- liu J, Zong Z, Zhang W, Chen Y, Wang X, Shen J, Yang C, Liu X, Deng H. Nicotinamide Mononucleotide Alleviates LPS-Induced Inflammation and Oxidative Stress via Decreasing COX-2 Expression in Macrophages. Front Mol Biosci. 2021 Jul 6;8:702107.
- Jiang Y, Deng Y, Pang H, Ma T, Ye Q, Chen Q, Chen H, Hu Z, Qin CF, Xu Z. Treatment of SARS-CoV-2-induced pneumonia with NAD+ and NMN in two mouse models. Cell Discov. 2022 Apr 29;8(1):38.
- Okabe K, Yaku K, Uchida Y, Fukamizu Y, Sato T, Sakurai T, Tobe K, Nakagawa T. Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects. Front Nutr. 2022 Apr 11;9:868640.