Coenzyme NAD+ is essential in cellular bioenergy and adaptive stress responses. Depletion of NAD+ has become a fundamental feature of aging and may predispose to a variety of chronic diseases.
Maintaining NAD+ levels is important for cells with high energy requirements and mature neuronal function.
NAD+ depletion has been detected in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, cardiovascular disease, and muscle atrophy.
There is growing evidence that the amount of NAD+ in both males and females after puberty is inversely related to age, and that age-dependent declines in β-nicotinamide adenine dinucleotide are common in many species.
Restoring intracellular NAD+ levels through interventions may delay aging and prevent the development of some age-related diseases.
Numerous studies have explored the effects of β-nicotinamide adenine dinucleotide on the lifespan and health of yeast, nematodes, fruit flies, and mice, and Table 1 shows the health benefits of NAD+ supplementation for various tissues in mice in selected studies.
| tissue | recruitment | Benefits |
| brain | 12 mmol/L | It can improve mitochondrial morphology and function and protect neurons |
| eye | 100 or 300 mg/kg/day | Prevents age-related decline in rod and cone function |
| muscle | 500 mg/kg/day | Reverses age-related muscle atrophy and inflammation, impaired insulin signaling, and insulin-stimulated glucose uptake |
| 300 mg/kg/day | Improved micronucleus markers and mitochondrial function | |
| liver | 300 or 500 mg/kg/day | Improves hepatic insulin sensitivity, reduces oxidative stress and improves inflammatory response, immune response and lipid metabolism |
| pancreas | 500 mg/kg/day | Improves glucose-stimulated insulin secretion |
Aging is the biggest risk factor for neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease and hearing loss.
Recent studies in animal models of Alzheimer’s disease have shown that beta-amyloid plaques, tau tangles, and mitochondrial dysfunction are key features of the disease.
Strategies to increase intracellular NAD+ are considered as potential novel therapies for Alzheimer’s disease.
For example, NAD+ can improve mitochondrial dysfunction and neuronal death in Alzheimer’s disease model mice, and can also prevent cognitive dysfunction caused by beta-amyloid oligomers.
Hearing loss is a common feature associated with advanced age, and noise exposure is the leading cause of this loss.
Intense noise exposure may lead to direct mechanical damage to cochlear hair cells and may trigger the delayed death of these auditory sensory neurons.
NAD+ administration has been found to protect mice from transient and permanent noise-induced hearing loss.
Cisplatin chemotherapy also causes chemical damage to the inner ear in cancer patients, and increased NAD+ protects against cisplatin induced cochlear damage by inhibiting oxidative stress, DNA damage, and inflammatory responses in mice.
Nowadays, the increase of the older people population brings a heavy burden to the family and society.
Lifestyle interventions, such as healthy eating and exercise, are ways to improve health and quality of life.
Not everyone at risk for age-related diseases is willing or able to follow these lifestyles.
NAD+ could be a promising candidate against normal aging and age-related diseases.
How to scientifically supplement NAD+?
The leading experts of NADclinic, a pioneer in molecular medicine, formed a top scientific research team, and after years of research, the original NAD+ exogenous supplement technology.
They found countless potential health benefits offered by NAD+IV, including cell optimization and reversing aging, among others.
NADclinic focused on developing and delivering innovative offline NAD+ (nicotinamide adenine dinucleotide) intravenous therapy options. These programs can help you alleviate adverse mental and physical conditions caused by lifestyle and age factors.
These common behaviors are undermining our physical and mental health, affecting our careers, family lives, relationships, and emotional connections.
NADclinic dedicated to the study of cell regeneration, mainly aimed at promoting brain regeneration and personal optimization of treatment.
In addition, we have made progress in the treatment of chronic fatigue, menopause, androgen, stress and anxiety, anti-aging, alcohol, prescription drug detoxification and other complementary therapies.
Our experienced medical teams, based in the Medical District of Harley Street, London (27 Wimpole Street, W1G 8GN) and Cape Town, South Africa, have a century-old track record in the field.
Due to the effectiveness of nicotinamide adenine dinucleotide for anti-aging, optimizing the brain, restoring physical function and other aspects, it has now become a common therapy. Although there are many forms of supplementation, they are not all equally effective.
When NAD+ injected intravenously, the compound travels through the bloodstream to every part of the body. Compared to oral, it will have a better effect.
At present, the most cutting-edge nicotinamide adenine dinucleotide therapy is available at the authoritative NADpole St (27 Wimpole St, London W1G 8GN) in the UK, and the effect is very significant.
If you are only new to NAD products, you can also start with NAD+ supplements.
Optima Max: promotes full absorption of NAD+
Optima Max encapsulates NAD+ molecules with multi-layer, multi-capsule liposomes, enabling them to resist gastric acid consumption and reach the small intestine.
Liposomes attached with special phosphate molecular structures, which can bind to receptors on the surface of small intestine cells, so that the liposomes can successfully penetrate the cell membrane barrier and enter the cell interior, releasing nicotinamide adenine dinucleotide molecules.
The NAD+ molecule completely absorbed and activates the DNA repair enzyme PARP1 to play an anti-aging role.
Optima Max: opens the internal cycle of NAD+
Any NAD+ precursor converted to nicotinamide adenine dinucleotide and involved in anti-aging and gene repair work will converted to NAM (niacinamide).
And that NAM, converted by an enzyme called NAMPT, can turn into NAN, and then regenerate nicotinamide adenine dinucleotide, and so on, and this pathway is the internal circulation of nicotinamide adenine dinucleotide.
Optima Max can directly provide a sufficient amount of NAD+ molecules, while keeping a certain proportion of nicotinamide adenine dinucleotide, NA and NAM components into the cell, which can activate the enzyme mediated by NAMPT, so that NAD+ can orderly synthesized in the body and form an internal circulation state.
It is difficult to distinguish between true and false NAD+ supplements on the market, so we should choose carefully. Optima Max is currently NADclinic’s cutting-edge supplement with up to 90 percent NAD+, making it the most effective anti-aging agent.