impact of NMN on ten most common diseases in world

Studies have shown that NMN has a positive effect on the ten most common diseases in the world.

These include diabetes, cardiovascular and cerebrovascular diseases, neurodegenerative diseases, influenza and pneumonia, obesity, liver disease, tuberculosis, infectious diseases and injuries, and digestive diseases.

1. diabetes

As a supplement, NMN can activate and repair protein genes associated with longevity, which has the effect of regulating blood sugar and reducing insulin resistance.

This means that NMN can help improve insulin sensitivity and improve the process by which glucose enters cells from the blood, while restoring the function of islet cells.

This is very important for people with diabetes because insulin resistance and abnormal insulin function are the core problems of diabetes.

2. Cardiovascular and cerebrovascular diseases

Cardiovascular and cerebrovascular diseases are common health problems in middle-aged and elderly people.

With the increase of age, the blood flow rate in the human body will slow down, which may lead to hyperlipidemia, blood viscosity, atherosclerosis and hypertension and other problems, resulting in ischemic or hemorrhagic damage to the heart, brain and systemic tissues.

NMN has a positive impact on cardiovascular and cerebrovascular diseases through the following mechanisms:

Repair blood vessels:

NMN can enhance the relaxation degree of endothelial cells, mainly because NMN can effectively increase the content of NAD+ after entering the cells.

NAD+ can enhance the expression of acetylase SIRTUINS, thereby reducing the attack of free radicals on mitochondria in cells, maintaining the function of mitochondria and enabling them to produce nitric oxide.

The role of nitric oxide is to relax the vascular endothelial cells, restore the vasodilation ability, and then promote the neurovascular coupling, so that the blood flow smoothly.

NMN also prevents cardiovascular disease by increasing high-density lipoprotein, reducing the oxidation of low-density lipoprotein, and alleviating the inflammatory response of macrophages.

Anti-inflammatory and antioxidant:

NMN has anti-inflammatory and antioxidant effects that can reduce blood vessel inflammation, improve blood vessel function and reduce the risk of cardiovascular disease.

This anti-inflammatory effect helps to reduce atherosclerotic plaque formation, increase plaque stability, thereby reducing the risk of plaque rupture, and improve blood flow.

Improve memory dysfunction and neuron damage:

NMN can also alleviate memory dysfunction and neuronal damage in some cases, and attenuate inflammatory responses and oxidative stress associated with cardiovascular and cerebrovascular diseases.

3. Neurodegenerative disease

Neurodegenerative diseases are a class of diseases closely related to aging, such as Alzheimer's disease, Parkinson's disease, etc. These diseases are usually accompanied by the gradual degeneration and loss of function of brain neurons.

NMN can directly increase the concentration of NAD+ in the brain.

NAD+ is a key metabolite involved in energy metabolism, genomic stabilization, mitochondrial homeostasis, adaptive stress response, and cell survival.

By increasing the level of NAD+, NMN helps maintain the healthy state of the brain's neurons, thereby slowing the progression of neurodegenerative diseases.

NMN can inhibit the accumulation of abnormal proteins and reduce synaptic loss.

In neurodegenerative diseases such as Alzheimer's disease, the accumulation of abnormal proteins and loss of synapses are important causes of loss of neuronal function.

By inhibiting these abnormal processes, NMN helps protect neurons in the brain from damage.

NMN can also promote the regeneration of aging brain vessels.

Cerebrovascular is an important channel for brain neurons to obtain nutrients and oxygen, and the decline of its regenerative ability will aggravate the degeneration and death of neurons.

NMN helps to improve the symptoms of neurodegenerative diseases by promoting cerebral vascular regeneration and providing more adequate nutrients and oxygen to brain neurons.

4. pneumonia

Studies have shown that NMN supplementation can increase the vitality and number of immune cells, such as natural killer cells and lymphocytes, which are essential for fighting viral, bacterial, and other pathogen infections.

NMN can reduce the aging of lung cells and promote lung health.

With age, lung function gradually declines, and at the same time, the level of NAD+ within cells decreases.

NMN supplementation can increase the synthesis of NAD+, thereby maintaining mitochondrial function and protecting nuclear DNA integrity against replication and stress-induced aging.

These effects help maintain the normal function of lung cells and reduce the occurrence of lung diseases.

NMN also has antioxidant effects, which can neutralize free radicals and reduce the damage of lung cells caused by oxidative stress.

The antioxidant effects of NMN help protect the lungs from oxidative stress and free radical damage caused by exposure to air pollutants, tobacco smoke and other harmful substances.

5. Liver protection

The liver is the chemical plant of the human body, which undertakes multiple tasks such as digestion, metabolism and detoxification, and its health status is crucial to the body.

NMN can increase the level of NAD+ in the liver.

NAD+ is an important coenzyme in cells and is involved in a variety of life activities.

As a precursor to NAD+, NMN can be quickly absorbed by the body and converted into NAD+, thus helping the liver to better perform its physiological functions.

NMN can improve liver disease caused by chronic alcohol consumption.

Alcohol in the human body metabolism process will produce harmful substances, causing damage to the liver.

By increasing the level of NAD+ in the liver, NMN accelerates the catabolism of alcohol and reduces the damage of alcohol to the liver.

NMN can also increase the activity of enzymes in the liver, which helps the liver to be better protected.

NMN can also prevent liver fibrosis.

Liver fibrosis is a chronic liver disease that can progress to cirrhosis or even liver cancer if left untreated.

The study found that NMN can increase the amount of 15-PGDH protein and reduce the level of the lipid PGE2 that causes liver fibrosis, thus playing a role in preventing liver fibrosis.

6. obesity

Obesity is a global health problem associated with an increased risk of multiple chronic diseases such as cardiovascular disease, diabetes, and certain cancers.

In recent years, several studies have suggested that NMN may have an effect on obesity through multiple mechanisms.

NMN can increase the level of NAD+ (nicotinamide adenine dinucleotide) in the body.

NAD+ plays a key role in cellular energy metabolism, and obesity may lead to decreased levels of NAD+.

By supplementing with NMN, NAD+ levels can be restored, thereby improving the energy metabolism of cells, promoting fat burning and reducing fat accumulation.

NMN may influence obesity by regulating insulin sensitivity.

Obesity is often associated with insulin resistance, a state in which the body's response to insulin is diminished.

NMN can help control blood sugar and reduce fat accumulation by increasing insulin sensitivity and promoting normal insulin secretion.

This has important implications for the prevention and treatment of obesity and type 2 diabetes associated with insulin resistance.

NMN may also ameliorate obesity by regulating lipid metabolism.

Studies have shown that NMN can influence the activity of SIRT1, a "longevity protein" in lipid cells that plays a key role in lipid metabolism and mitochondrial function.

By increasing the activity of SIRT1, NMN may optimize the metabolic status of key proteins and directly affect the mitochondrial function of lipid cells, thereby reducing fat accumulation and obesity caused by abnormal lipid metabolism